Some sequelae of oral candidiasis, including but not limited to ulcers, severe stomatitis, and mucosal hypersensitivity, reduce patient quality of life. Superficial candidiasis in the oral and oesophageal mucosa occurs in patients with HIV infection, transplant patients, and patients receiving cancer therapy, due to the increased susceptibility of these patients to fungal colonization and infection in upper gastrointestinal tract mucosa. Candida species initially colonize mucosal surfaces in the oral cavity, intestinal epithelia, or vagina, where they proliferate and cause mucosal infections in immunocompromised patients. Candida is the fourth leading microorganism responsible for human bloodstream infection in the USA and causes severe systemic candidiasis (deep mycosis), with 40% mortality. They can also cause severe infections in immunocompromised hosts. Keywords: Stichopus japonicus holotoxin Candida oral care elderly in nursing homeĬandida species are indigenous microorganisms present asymptomatically in a variety of different animal species. japonicus jelly has the potential to reduce the oral Candida load in the elderly in nursing homes. The sea cucumber jelly showed inhibitory effects on the oral Candida. Nine individuals took a control jelly without S. Eight individuals in the nursing home took the sea cucumber jelly for a week and their oral Candida were counted before and after the intervention. The holotoxins worked as a fungicide, and their minimum inhibitory concentrations for Candida albicans were 7 |ig/mL. The jelly contained a hydrolysate of the sea cucumber Stichopus japonicus, which contained triterpene glycosides called holotoxins. Received: 9 October 2013 in revised form: 15 November 2013 / Accepted: 26 November 2013 / Published: 11 December 2013Ībstract: We conducted a double-blind randomized controlled study of elderly individuals in a nursing home to investigate the effect of the consumption of jelly containing sea cucumber on their oral Candida load. The Effect of Eating Sea Cucumber Jelly on Candida Load in the Oral Cavity of Elderly Individuals in a Nursing Homeġ2 2 1 2 Akira Yano '*, Akiko Abe, Fumie Aizawa, Hidetoshi Yamada, Kentaro Minami ,ġ Iwate Biotechnology Research Center, Kitakami, Iwate 024-0003, Japan E-Mail: of Oral Health, Iwate Medical University School of Dentistry, Morioka 020-8505, Japan E-Mails: (A.A.) (F.A.) (K.M.) (M.M.) (M.K.)

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